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Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL
Oncogenic mutations in NOTCH1 are present in over 50% of T-cell lymphoblastic leukemias (T-ALLs). Activation of NOTCH1 requires a double proteolytic processing in the extracellular region of the receptor (S2) and in the transmembrane domain (S3). Currently, anti-NOTCH1 therapies based on inhibition...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165074/ https://ncbi.nlm.nih.gov/pubmed/21625236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.130 |
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