Why Human Cytochrome P450c21 is a Progesterone 21-Hydroxylase

Human cytochrome P450c21 (steroid 21-hydroxylase, CYP21A2)() catalyzes the 21-hydroxylation of progesterone (P4) and its preferred substrate 17α-hydroxyprogestrone (17OHP4). CYP21A2 activities, which are required for cortisol and aldosterone biosynthesis, involve the formation of energetically disfa...

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Bibliographische Detailangaben
Hauptverfasser: Mizrachi, Dario, Wang, Zhu, Sharma, Kamalesh K., Gupta, Manisha K., Xu, Keliang, Dwyer, Christopher R., Auchus, Richard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165045/
https://ncbi.nlm.nih.gov/pubmed/21446712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi102078e
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