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Minimization and Optimization of Designed β-Hairpin Folds
Mimimized β hairpins have provided additional data on the geometric preferences of Trp interactions in TW-loop-WT motifs. This motif imparts significant fold stability to peptides as short as 8 residues. High-resolution NMR structures of a 16- (KKWTWNPATGKWTWQE, ΔG(U)(298) ≥ +7 kJ/mol) and 12-residu...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164952/ https://ncbi.nlm.nih.gov/pubmed/16669679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja054971w |
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