NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus

BACKGROUND: Children with germline mutations in TLR3, UNC93B1, TRAF3 and STAT1 are prone to herpes simplex virus-1 (HSV-1) encephalitis (HSE), owing to impaired TLR3-triggered, UNC-93B-dependent, interferon (IFN)-α/β and/or -λ-mediated STAT1-dependent immunity. OBJECTIVE: We explore here the molecul...

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Detalhes bibliográficos
Main Authors: Audry, Magali, Ciancanelli, Michael, Yang, Kun, Cobat, Aurelie, Chang, Huey-Hsuan, Sancho-Shimizu, Vanessa, Lorenzo, Lazaro, Niehues, Tim, Reichenbach, Janine, Li, Xiao-Xia, Israel, Alain, Abel, Laurent, Casanova, Jean-Laurent, Zhang, Shen-Ying, Jouanguy, Emmanuelle, Puel, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164951/
https://ncbi.nlm.nih.gov/pubmed/21722947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2011.04.059
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