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Synthesis of Substituted Chromanones: An Organocatalytic Aldol/oxa-Michael Reaction

[Image: see text] A diastereoselective organocatalytic aldol/oxa-Michael reaction has been developed to efficiently deliver medicinally relevant 2,3-ring substituted chromanones. Development of this synthetic strategy revealed an unexpected kinetic anti-Saytzeff elimination; an origin for the observ...

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Autors principals: Butler, Jeffrey D., Conrad, Wayne E., Lodewyk, Michael W., Fettinger, James C., Tantillo, Dean J., Kurth, Mark J.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164863/
https://ncbi.nlm.nih.gov/pubmed/20617821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol101221c
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