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Quantum Chemical Study of the Mechanism of Action of Vitamin K Carboxylase in Solvent

We investigate the post-translational generation of Gla (γ-carboxy glutamic acid) from Glu (glutamic acid) by vitamin K carboxylase (VKC) in solvent. VKC is thought to convert vitamin K, in the vitamin K cycle, to an alkoxide-epoxide form, which then reacts with CO(2) to generate an essential ingred...

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Bibliografiset tiedot
Päätekijät: WU, SANGWOOK, LIU, SHUBIN, DAVIS, CHARLES H., STAFFORD, DARREL W., PEDERSEN, LEE G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164839/
https://ncbi.nlm.nih.gov/pubmed/21892230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/qua.22740
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