The Choice of the Filtering Method in Microarrays Affects the Inference Regarding Dosage Compensation of the Active X-Chromosome

BACKGROUND: The hypothesis of dosage compensation of genes of the X chromosome, supported by previous microarray studies, was recently challenged by RNA-sequencing data. It was suggested that microarray studies were biased toward an over-estimation of X-linked expression levels as a consequence of t...

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Main Authors: Castagné, Raphaële, Rotival, Maxime, Zeller, Tanja, Wild, Philipp S., Truong, Vinh, Trégouët, David-Alexandre, Munzel, Thomas, Ziegler, Andreas, Cambien, François, Blankenberg, Stefan, Tiret, Laurence
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164665/
https://ncbi.nlm.nih.gov/pubmed/21912656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023956
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