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Batrachotoxin, Pyrethroids, and BTG 502 Share Overlapping Binding Sites on Insect Sodium Channels

Batrachotoxin (BTX), a steroidal alkaloid, and pyrethroid insecticides bind to distinct but allosterically coupled receptor sites on voltage-gated sodium channels and cause persistent channel activation. BTX presumably binds in the inner pore, whereas pyrethroids are predicted to bind at the lipid-e...

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Detalhes bibliográficos
Main Authors: Du, Yuzhe, Garden, Daniel, Khambay, Bhupinder, Zhorov, Boris S., Dong, Ke
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164329/
https://ncbi.nlm.nih.gov/pubmed/21680776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.072504
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