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Total Synthesis of (+)-SCH 351448

[Image: see text] A convergent synthesis of (+)-SCH 351448 (1), a monosodium salt of a C(2)-symmetric macrodiolide, is described. Our approach is based on a [4+2] annulation with a chiral allyl silane (anti-5c) to assemble the pyran subunits. Homodimerization was carried out in a stepwise fashion; i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhu, Kaicheng, Panek, James S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164292/
https://ncbi.nlm.nih.gov/pubmed/21834568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol201863b
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