Prolonged Half-life of Voriconazole in a CYP2C19 Homozygous Poor Metabolizer Receiving Vincristine Chemotherapy: Avoiding a Serious Adverse Drug Interaction

We report a case of prolonged half-life of voriconazole due to CYP2C19*2/*2 poor metabolizer genotype in a patient receiving vincristine chemotherapy. Voriconazole was discontinued three days before start of vincristine to avoid a serious drug interaction. Therapeutic drug monitoring and genotyping...

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Main Authors: Moriyama, Brad, Falade, Oluwaseun, Leung, Janice, Penzak, Scott R., JJingo, Caroline, Huang, Xuan, Henning, Stacey A., Wilson, Wyndham H., Walsh, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164277/
https://ncbi.nlm.nih.gov/pubmed/21615537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1439-0507.2011.02016.x
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