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Rationalizing 5000-Fold Differences in Receptor-Binding Rate Constants of Four Cytokines
The four cytokines erythropoietin (EPO), interleukin-4 (IL4), human growth hormone (hGH), and prolactin (PRL) all form four-helix bundles and bind to type I cytokine receptors. However, their receptor-binding rate constants span a 5000-fold range. Here, we quantitatively rationalize these vast diffe...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164179/ https://ncbi.nlm.nih.gov/pubmed/21889455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.06.056 |
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