The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

Mutations in the SMAD4/DPC4 tumor suppressor gene, a key signal transducer in most TGFβ-related pathways, are involved in 50% of pancreatic cancers. Homozygous Smad4 mutant mice die before day 7.5 of embryogenesis. Mutant embryos have reduced size, fail to gastrulate or express a mesodermal marker,...

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Main Authors: Sirard, Christian, de la Pompa, José Luis, Elia, Andrew, Itie, Annick, Mirtsos, Christine, Cheung, Alison, Hahn, Stephan, Wakeham, Andrew, Schwartz, Lois, Kern, Scott E., Rossant, Janet, Mak, Tak W.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC316400/
https://ncbi.nlm.nih.gov/pubmed/9420335
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