The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

Mutations in the SMAD4/DPC4 tumor suppressor gene, a key signal transducer in most TGFβ-related pathways, are involved in 50% of pancreatic cancers. Homozygous Smad4 mutant mice die before day 7.5 of embryogenesis. Mutant embryos have reduced size, fail to gastrulate or express a mesodermal marker,...

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Publié dans:	Genes Dev
Auteurs principaux:	Sirard, Christian, de la Pompa, José Luis, Elia, Andrew, Itie, Annick, Mirtsos, Christine, Cheung, Alison, Hahn, Stephan, Wakeham, Andrew, Schwartz, Lois, Kern, Scott E., Rossant, Janet, Mak, Tak W.
Format:	Artigo
Langue:	Inglês
Publié:	Cold Spring Harbor Laboratory Press 1998
Sujets:	Research Paper
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316400/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9420335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.1.107
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