The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The major risk allele encodes an R620W amino acid change that alters B cell receptor (BCR) signaling involved in the regulation of central B cell tolerance. To assess whether th...

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Autors principals: Menard, Laurence, Saadoun, David, Isnardi, Isabelle, Ng, Yen-Shing, Meyers, Greta, Massad, Christopher, Price, Christina, Abraham, Clara, Motaghedi, Roja, Buckner, Jane H., Gregersen, Peter K., Meffre, Eric
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163953/
https://ncbi.nlm.nih.gov/pubmed/21804190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45790
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