Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

Lithium is the first-line therapy for bipolar disorder. However, its therapeutic target remains controversial. Candidates include inositol monophosphatases, glycogen synthase kinase-3 (GSK-3), and a β-arrestin-2/AKT/protein phosphatase 2A (β-arrestin-2/AKT/PP2A) complex that is known to be required...

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Bibliografiske detaljer
Main Authors: O’Brien, W. Timothy, Huang, Jian, Buccafusca, Roberto, Garskof, Julie, Valvezan, Alexander J., Berry, Gerard T., Klein, Peter S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163947/
https://ncbi.nlm.nih.gov/pubmed/21821916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45194
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