Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice

Hematopoietic stem cell (HSC) homeostasis depends on the balance between self renewal and lineage commitment, but what regulates this decision is not well understood. Using loss-of-function approaches in mice, we found that glycogen synthase kinase–3 (Gsk3) plays a pivotal role in controlling the de...

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Detalhes bibliográficos
Main Authors: Huang, Jian, Zhang, Yi, Bersenev, Alexey, O’Brien, W. Timothy, Tong, Wei, Emerson, Stephen G., Klein, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786808/
https://ncbi.nlm.nih.gov/pubmed/19959876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40572
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