Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans

Hirschsprung (HSCR) disease is a complex genetic disorder attributed to a failure of the enteric neural crest cells (ENCCs) to form ganglia in the hindgut. Hedgehog and Notch are implicated in mediating proliferation and differentiation of ENCCs. Nevertheless, how these signaling molecules may inter...

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Detaylı Bibliyografya
Asıl Yazarlar: Ngan, Elly Sau-Wai, Garcia-Barceló, Maria-Mercè, Yip, Benjamin Hon-Kei, Poon, Hiu-Ching, Lau, Sin-Ting, Kwok, Carmen Ka-Man, Sat, Eric, Sham, Mai-Har, Wong, Kenneth Kak-Yuen, Wainwright, Brandon J., Cherny, Stacey S., Hui, Chi-Chung, Sham, Pak Chung, Lui, Vincent Chi-Hang, Tam, Paul Kwong-Hang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163945/
https://ncbi.nlm.nih.gov/pubmed/21841314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43737
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