Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans

Hirschsprung (HSCR) disease is a complex genetic disorder attributed to a failure of the enteric neural crest cells (ENCCs) to form ganglia in the hindgut. Hedgehog and Notch are implicated in mediating proliferation and differentiation of ENCCs. Nevertheless, how these signaling molecules may inter...

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Main Authors: Ngan, Elly Sau-Wai, Garcia-Barceló, Maria-Mercè, Yip, Benjamin Hon-Kei, Poon, Hiu-Ching, Lau, Sin-Ting, Kwok, Carmen Ka-Man, Sat, Eric, Sham, Mai-Har, Wong, Kenneth Kak-Yuen, Wainwright, Brandon J., Cherny, Stacey S., Hui, Chi-Chung, Sham, Pak Chung, Lui, Vincent Chi-Hang, Tam, Paul Kwong-Hang
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2011
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163945/
https://ncbi.nlm.nih.gov/pubmed/21841314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43737
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