Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

Reduced bone morphogenetic protein receptor 2 (BMPR2) expression in patients with pulmonary arterial hypertension (PAH) can impair pulmonary arterial EC (PAEC) function. This can adversely affect EC survival and promote SMC proliferation. We hypothesized that interventions to normalize expression of...

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Main Authors: Alastalo, Tero-Pekka, Li, Molong, de Jesus Perez, Vinicio, Pham, David, Sawada, Hirofumi, Wang, Jordon K., Koskenvuo, Minna, Wang, Lingli, Freeman, Bruce A., Chang, Howard Y., Rabinovitch, Marlene
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163943/
https://ncbi.nlm.nih.gov/pubmed/21821917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43382
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