Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

Reduced bone morphogenetic protein receptor 2 (BMPR2) expression in patients with pulmonary arterial hypertension (PAH) can impair pulmonary arterial EC (PAEC) function. This can adversely affect EC survival and promote SMC proliferation. We hypothesized that interventions to normalize expression of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Alastalo, Tero-Pekka, Li, Molong, de Jesus Perez, Vinicio, Pham, David, Sawada, Hirofumi, Wang, Jordon K., Koskenvuo, Minna, Wang, Lingli, Freeman, Bruce A., Chang, Howard Y., Rabinovitch, Marlene
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163943/
https://ncbi.nlm.nih.gov/pubmed/21821917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43382
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