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Germline Transgenic Pigs by Sleeping Beauty Transposition in Porcine Zygotes and Targeted Integration in the Pig Genome

Genetic engineering can expand the utility of pigs for modeling human diseases, and for developing advanced therapeutic approaches. However, the inefficient production of transgenic pigs represents a technological bottleneck. Here, we assessed the hyperactive Sleeping Beauty (SB100X) transposon syst...

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Hlavní autoři: Garrels, Wiebke, Mátés, Lajos, Holler, Stephanie, Dalda, Anna, Taylor, Ulrike, Petersen, Björn, Niemann, Heiner, Izsvák, Zsuzsanna, Ivics, Zoltán, Kues, Wilfried A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163581/
https://ncbi.nlm.nih.gov/pubmed/21897845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023573
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