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Germline Transgenic Pigs by Sleeping Beauty Transposition in Porcine Zygotes and Targeted Integration in the Pig Genome

Genetic engineering can expand the utility of pigs for modeling human diseases, and for developing advanced therapeutic approaches. However, the inefficient production of transgenic pigs represents a technological bottleneck. Here, we assessed the hyperactive Sleeping Beauty (SB100X) transposon syst...

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Bibliographische Detailangaben
Hauptverfasser: Garrels, Wiebke, Mátés, Lajos, Holler, Stephanie, Dalda, Anna, Taylor, Ulrike, Petersen, Björn, Niemann, Heiner, Izsvák, Zsuzsanna, Ivics, Zoltán, Kues, Wilfried A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163581/
https://ncbi.nlm.nih.gov/pubmed/21897845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023573
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