Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling

Antigenic stimulation of the B-cell receptor (BCR) is a central event in the immune response. In contrast, antigen bound to IgG negatively regulates signals from the BCR by cross-linking it to the inhibitory receptor FcγRIIB. Here we show that upon cross-linking of BCR or BCR with FcγRIIB, the rasGA...

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Détails bibliographiques
Auteurs principaux: Yamanashi, Yuji, Tamura, Toshiki, Kanamori, Toshihide, Yamane, Hidehiro, Nariuchi, Hideo, Yamamoto, Tadashi, Baltimore, David
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2000
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC316343/
https://ncbi.nlm.nih.gov/pubmed/10640270
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