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Akt-Mediated Transactivation of the S1P(1) Receptor in Caveolin-Enriched Microdomains Regulates Endothelial Barrier Enhancement by Oxidized Phospholipids

Endothelial cell (EC) barrier dysfunction results in increased vascular permeability, leading to increased mass transport across the vessel wall and leukocyte extravasation, the key mechanisms in pathogenesis of tissue inflammation and edema. We have previously demonstrated that OxPAPC (oxidized 1-p...

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Autors principals: Singleton, Patrick A., Chatchavalvanich, Santipongse, Fu, Panfeng, Xing, Junjie, Birukova, Anna A., Fortune, Jennifer A., Klibanov, Alexander M., Garcia, Joe G. N., Birukov, Konstantin G.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163385/
https://ncbi.nlm.nih.gov/pubmed/19286607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.193367
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