An essential role in liver development for transcription factor XBP-1

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hema...

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Main Authors: Reimold, Andreas M., Etkin, Amit, Clauss, Isabelle, Perkins, Andrew, Friend, Daniel S., Zhang, John, Horton, Heidi F., Scott, Andrew, Orkin, Stuart H., Byrne, Michael C., Grusby, Michael J., Glimcher, Laurie H.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2000
Teme:
Research Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC316338/
https://ncbi.nlm.nih.gov/pubmed/10652269
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