An essential role in liver development for transcription factor XBP-1

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hema...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Reimold, Andreas M., Etkin, Amit, Clauss, Isabelle, Perkins, Andrew, Friend, Daniel S., Zhang, John, Horton, Heidi F., Scott, Andrew, Orkin, Stuart H., Byrne, Michael C., Grusby, Michael J., Glimcher, Laurie H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2000
Pynciau:
Research Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC316338/
https://ncbi.nlm.nih.gov/pubmed/10652269
Tagiau: Ychwanegu Tag
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