An essential role in liver development for transcription factor XBP-1

XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hema...

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Main Authors: Reimold, Andreas M., Etkin, Amit, Clauss, Isabelle, Perkins, Andrew, Friend, Daniel S., Zhang, John, Horton, Heidi F., Scott, Andrew, Orkin, Stuart H., Byrne, Michael C., Grusby, Michael J., Glimcher, Laurie H.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2000
Assuntos:
Research Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC316338/
https://ncbi.nlm.nih.gov/pubmed/10652269
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