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A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection
Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer US
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3162965/ https://ncbi.nlm.nih.gov/pubmed/21626281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10519-011-9475-0 |
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