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Powerful Regression-Based Quantitative-Trait Linkage Analysis of General Pedigrees

We present a new method of quantitative-trait linkage analysis that combines the simplicity and robustness of regression-based methods and the generality and greater power of variance-components models. The new method is based on a regression of estimated identity-by-descent (IBD) sharing between re...

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Autors principals: Sham, Pak C., Purcell, Shaun, Cherny, Stacey S., Abecasis, Gonçalo R.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Human Genetics 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC379157/
https://ncbi.nlm.nih.gov/pubmed/12111667
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