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Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures

BACKGROUND: Activation of glial cells via toll-like receptors (TLRs) and other intracellular pathogen recognition receptors promotes the release of potentially toxic acute phase reactants such as TNFα and nitric oxide into the extracellular space. As such, prolonged glial activation, as is thought t...

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Detalhes bibliográficos
Main Authors: Steelman, Andrew J, Li, Jianrong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162898/
https://ncbi.nlm.nih.gov/pubmed/21812954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-89
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