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The Immunoglobulin Heavy Chain Gene 3’ Enhancers Induce Bcl2 Deregulation and Lymphomagenesis in Murine B Cells
Human follicular B-cell lymphoma is associated with the t(14;18) chromosomal translocation that juxtaposes the Bcl2 proto-oncogene with the immunoglobulin heavy chain (Igh) locus, resulting in the deregulated expression of Bcl2. Our previous studies have shown that the Igh 3’ enhancers deregulate Bc...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3162065/ https://ncbi.nlm.nih.gov/pubmed/21606958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.115 |
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