Lowe Syndrome Protein OCRL1 Supports Maturation of Polarized Epithelial Cells

Mutations in the inositol polyphosphate 5-phosphatase OCRL1 cause Lowe Syndrome, leading to cataracts, mental retardation and renal failure. We noted that cell types affected in Lowe Syndrome are highly polarized, and therefore we studied OCRL1 in epithelial cells as they mature from isolated indivi...

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Bibliografski detalji
Glavni autori: Grieve, Adam G., Daniels, Rachel D., Sanchez-Heras, Elena, Hayes, Matthew J., Moss, Stephen E., Matter, Karl, Lowe, Martin, Levine, Timothy P.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162020/
https://ncbi.nlm.nih.gov/pubmed/21901156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024044
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