Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands

(11)C-PBR28 PET can detect the 18-kDa translocator protein (TSPO) expressed within macrophages. However, quantitative evaluation of the signal in brain tissue from donors with multiple sclerosis (MS) shows that PBR28 binds the TSPO with high affinity (binding affinity [K(i)], ~4 nM), low affinity (K...

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Detalhes bibliográficos
Main Authors: Owen, David R.J., Gunn, Roger N., Rabiner, Eugenii A., Bennacef, Idriss, Fujita, Masahiro, Kreisl, William C., Innis, Robert B., Pike, Victor W., Reynolds, Richard, Matthews, Paul M., Parker, Christine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161826/
https://ncbi.nlm.nih.gov/pubmed/21149489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.110.079459
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