Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

BACKGROUND: We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated whether FXR activation is repressed in the ileum and...

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Detalhes bibliográficos
Main Authors: Nijmeijer, Rian M., Gadaleta, Raffaella M., van Mil, Saskia W. C., van Bodegraven, Adriaan A., Crusius, J. Bart A., Dijkstra, Gerard, Hommes, Daan W., de Jong, Dirk J., Stokkers, Pieter C. F., Verspaget, Hein W., Weersma, Rinse K., van der Woude, C. Janneke, Stapelbroek, Janneke M., Schipper, Marguerite E. I., Wijmenga, Cisca, van Erpecum, Karel J., Oldenburg, Bas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161760/
https://ncbi.nlm.nih.gov/pubmed/21887309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023745
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