Pharmacological Activation of the Bile Acid Nuclear Farnesoid X Receptor Is Feasible in Patients with Quiescent Crohn's Colitis

BACKGROUND: The bile acid-activated nuclear receptor Farnesoid X Receptor (FXR) is critical in maintaining intestinal barrier integrity and preventing bacterial overgrowth. Patients with Crohn's colitis (CC) exhibit reduced ileal FXR target gene expression. FXR agonists have been shown to ameli...

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Detalhes bibliográficos
Main Authors: van Schaik, Fiona D. M., Gadaleta, Raffaella M., Schaap, Frank G., van Mil, Saskia W. C., Siersema, Peter D., Oldenburg, Bas, van Erpecum, Karel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506649/
https://ncbi.nlm.nih.gov/pubmed/23189156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049706
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