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Robust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of Pins
Cellular signaling pathways exhibit complex response profiles with features such as thresholds and steep activation (i.e. ultrasensitivity). In a reconstituted mitotic spindle orientation pathway, activation of Drosophila Pins (LGN in mammals) by Gαi is ultrasensitive (apparent Hill coefficient of 3...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3161515/ https://ncbi.nlm.nih.gov/pubmed/21855794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.030 |
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