Identification of an In Vivo MEK/WOX1 Complex as a Master Switch for Apoptosis in T Cell Leukemia

Not all leukemia T cells are susceptible to high levels of phorbol myristate acetate (PMA)–mediated apoptosis. At micromolar levels, PMA induces apoptosis of Jurkat T cells by causing mitochondrial polarization/de-polarization, release of cytosolic granules, and DNA fragmentation. Chemical inhibitor...

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Bibliographic Details
Main Authors: Lin, Hsin-Ping, Chang, Jean-Yun, Lin, Sing-Ru, Lee, Ming-Hui, Huang, Shenq-Shyang, Hsu, Li-Jin, Chang, Nan-Shan
Format: Artigo
Language:Inglês
Published: SAGE Publications 2011
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161421/
https://ncbi.nlm.nih.gov/pubmed/21901168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601911418498
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