Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation

Whether tumor suppressor WWOX (WW domain-containing oxidoreductase) stimulates immune cell maturation is largely unknown. Here, we determined that Tyr-33-phosphorylated WWOX physically binds non-phosphorylated ERK and IκBα in immature acute lymphoblastic leukemia MOLT-4 T cells and in the naïve mous...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Huang, Shenq-Shyang, Su, Wan-Pei, Lin, Hsin-Pin, Kuo, Hsiang-Ling, Wei, Hsiao-Ling, Chang, Nan-Shan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016130/
https://ncbi.nlm.nih.gov/pubmed/27339895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716167
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