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Total synthesis of (-)-CP(2)-disorazole C(1)
[Image: see text] The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (-)-disorazole C(1) was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC(50) determinatio...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160746/ https://ncbi.nlm.nih.gov/pubmed/21739942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol2015994 |
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