Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

The Polycomb repressive complex 1 (PRC1) mediates gene silencing, in part by monoubiquitination of histone H2A on lysine 119 (uH2A). Bmi1 and Ring1b are critical components of PRC1 that heterodimerize via their N-terminal RING domains to form an active E3 ubiquitin ligase. We have determined the cry...

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Détails bibliographiques
Auteurs principaux: Bentley, Matthew L, Corn, Jacob E, Dong, Ken C, Phung, Qui, Cheung, Tommy K, Cochran, Andrea G
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160663/
https://ncbi.nlm.nih.gov/pubmed/21772249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.243
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