Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

RAD52 protein has an important role in homology-directed DNA repair by mediating RAD51 nucleoprotein filament formation on single-stranded DNA (ssDNA) protected by replication protein-A (RPA) and annealing of RPA-coated ssDNA. In human, cellular response to DNA damage includes phosphorylation of RAD...

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Main Authors: Honda, Masayoshi, Okuno, Yusuke, Yoo, Jungmin, Ha, Taekjip, Spies, Maria
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160658/
https://ncbi.nlm.nih.gov/pubmed/21804533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.238
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