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Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis
New pleuromutilin-like compounds were synthesized in approximately 11 steps from 3-allylcyclopent-2-enone by a strategy featuring sequential carbonyl addition reactions. Several analogs possessing the C14 tiamulin ester side chain displayed activity in a Mycobacterium tuberculosis mc(2)7000 assay. T...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160647/ https://ncbi.nlm.nih.gov/pubmed/21874155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C1SC00116G |
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