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Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells

BACKGROUND: Caspase-8 is a key upstream mediator in death receptor-mediated apoptosis and also participates in mitochondria-mediated apoptosis via cleavage of proapoptotic Bid. However, the role of caspase-8 in p53- and p73-dependent apoptosis induced by genotoxic drugs remains unclear. We recently...

詳細記述

保存先:
書誌詳細
主要な著者: Liu, Juan, Uematsu, Hiroshi, Tsuchida, Nobuo, Ikeda, Masa-Aki
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160414/
https://ncbi.nlm.nih.gov/pubmed/21801448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-95
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