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Policing Parkin with a UblD
Parkin, a ubiquitin ligase of the RING-IBR-RING family, is mutated in familial Parkinsonism. Exciting recent reports transform our thinking of its catalytic activity, and reveal a new autoinhibitory mechanism that is abolished by disease mutations
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160263/ https://ncbi.nlm.nih.gov/pubmed/21772326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.223 |
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