Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

Cellular signal transduction is governed by multiple feedback mechanisms to elicit robust cellular decisions. The specific contributions of individual feedback regulators, however, remain unclear. Based on extensive time-resolved data sets in primary erythroid progenitor cells, we established a dyna...

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Main Authors: Bachmann, Julie, Raue, Andreas, Schilling, Marcel, Böhm, Martin E, Kreutz, Clemens, Kaschek, Daniel, Busch, Hauke, Gretz, Norbert, Lehmann, Wolf D, Timmer, Jens, Klingmüller, Ursula
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159971/
https://ncbi.nlm.nih.gov/pubmed/21772264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.50
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