Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

Cellular signal transduction is governed by multiple feedback mechanisms to elicit robust cellular decisions. The specific contributions of individual feedback regulators, however, remain unclear. Based on extensive time-resolved data sets in primary erythroid progenitor cells, we established a dyna...

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Bibliografische gegevens
Hoofdauteurs: Bachmann, Julie, Raue, Andreas, Schilling, Marcel, Böhm, Martin E, Kreutz, Clemens, Kaschek, Daniel, Busch, Hauke, Gretz, Norbert, Lehmann, Wolf D, Timmer, Jens, Klingmüller, Ursula
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159971/
https://ncbi.nlm.nih.gov/pubmed/21772264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2011.50
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