Therapeutic Efficacy of ABT-737, a Selective Inhibitor of BCL-2, in Small Cell Lung Cancer

Bcl-2 is a central regulator of cell survival that is overexpressed in the majority of small cell lung cancers (SCLC) and contributes to both malignant transformation and therapeutic resistance. We compared primary SCLC xenografts prepared from de novo human tumors with standard cell line–based xeno...

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Detalhes bibliográficos
Main Authors: Hann, Christine L., Daniel, Vincent C., Sugar, Elizabeth A., Dobromilskaya, Irina, Murphy, Sara C., Cope, Leslie, Lin, Xue, Hierman, Jared S., Wilburn, Daniel L., Watkins, D. Neil, Rudin, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159963/
https://ncbi.nlm.nih.gov/pubmed/18381439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-5031
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