Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer

BACKGROUND: New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape fro...

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Detalhes bibliográficos
Main Authors: Zinn, Rebekah L, Gardner, Eric E, Dobromilskaya, Irina, Murphy, Sara, Marchionni, Luigi, Hann, Christine L, Rudin, Charles M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599053/
https://ncbi.nlm.nih.gov/pubmed/23452820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-16
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