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Mutations in HCV non-structural genes do not contribute to resistance to nitazoxanide in replicon-containing cells

Nitazoxanide(NTZ) exhibits potent antiviral activity against hepatitis C virus (HCV) in cell culture. Previously, HCV replicon-containing cell lines resistant to NTZ were selected, but transfer the HCV NTZ-resistance phenotype was not observed following transfection of whole cell RNA. To further exp...

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Detalhes bibliográficos
Main Authors: Yon, Changsuek, Viswanathan, Prasanth, Rossignol, Jean-François, Korba, Brent
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159803/
https://ncbi.nlm.nih.gov/pubmed/21703309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2011.05.017
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