Temporal requirement for high SMN expression in SMA mice

Spinal muscular atrophy (SMA) is caused by loss of the survival motor neuron 1 gene (SMN1) and retention of the SMN2 gene, resulting in reduced SMN. SMA mice can be rescued with high expression of SMN in neurons, but when is this high expression required? We have developed a SMA mouse with inducible...

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Hlavní autoři: Le, Thanh T., McGovern, Vicki L., Alwine, Isaac E., Wang, Xueyong, Massoni-Laporte, Aurelie, Rich, Mark M., Burghes, Arthur H.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159555/
https://ncbi.nlm.nih.gov/pubmed/21672919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr275
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