Temporal requirement for high SMN expression in SMA mice

Spinal muscular atrophy (SMA) is caused by loss of the survival motor neuron 1 gene (SMN1) and retention of the SMN2 gene, resulting in reduced SMN. SMA mice can be rescued with high expression of SMN in neurons, but when is this high expression required? We have developed a SMA mouse with inducible...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Le, Thanh T., McGovern, Vicki L., Alwine, Isaac E., Wang, Xueyong, Massoni-Laporte, Aurelie, Rich, Mark M., Burghes, Arthur H.M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2011
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159555/
https://ncbi.nlm.nih.gov/pubmed/21672919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr275
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk