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Temporal requirement for high SMN expression in SMA mice

Spinal muscular atrophy (SMA) is caused by loss of the survival motor neuron 1 gene (SMN1) and retention of the SMN2 gene, resulting in reduced SMN. SMA mice can be rescued with high expression of SMN in neurons, but when is this high expression required? We have developed a SMA mouse with inducible...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Le, Thanh T., McGovern, Vicki L., Alwine, Isaac E., Wang, Xueyong, Massoni-Laporte, Aurelie, Rich, Mark M., Burghes, Arthur H.M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159555/
https://ncbi.nlm.nih.gov/pubmed/21672919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr275
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