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Conditional deletion of SMN in cell culture identifies functional SMN alleles
Spinal muscular atrophy (SMA) is caused by mutation or deletion of survival motor neuron 1 (SMN1) and retention of SMN2 leading to SMN protein deficiency. We developed an immortalized mouse embryonic fibroblast (iMEF) line in which full-length wild-type Smn (flwt-Smn) can be conditionally deleted us...
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| Foilsithe in: | Hum Mol Genet |
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| Main Authors: | , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Oxford University Press
2020
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7946624/ https://ncbi.nlm.nih.gov/pubmed/33075805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa229 |
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