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Plasminogen Regulates SDF-1/CXCR4-mediated Hematopoietic Stem Cell Mobilization by Activation of Matrix Metalloproteinase-9

OBJECTIVE: Granulocyte colony-stimulating factor (G-CSF) is a widespread therapeutic agent for stimulation of hematopoietic progenitor and stem cell (HPSC) mobilization from bone marrow (BM). Plasminogen (Plg) has been shown critical for HPSC mobilization. Here we investigated the role of Plg in G-C...

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Autors principals: Gong, Yanqing, Fan, Yi, Hoover-Plow, Jane
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159162/
https://ncbi.nlm.nih.gov/pubmed/21719761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.229583
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